Total synthesis of streptomycin.
نویسندگان
چکیده
منابع مشابه
Effects of streptomycin deprivation on enzyme synthesis in streptomycin-dependent Escherichia coli.
During growth of streptomycin-dependent strains of Escherichia coli in the absence of streptomycin (deprived growth), both constitutive and inducible synthesis of beta-galactosidase were preferentially inhibited. A similar preferential inhibition of constitutive and derepressed synthesis of alkaline phosphatase was observed. Catabolite repression accounted for part, but not all, of the inhibiti...
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The synthesis, purification, and biological properties of nitroguaiacol ether derivatives of streptomycin and their corresponding radioactive reduced products were examined. These derivatives are biologically active against gram-positive and gram-negative eubacteria and they are also photoreactive because of the presence of the nitroguaiacol group in the molecule. We demonstrated that these der...
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Nanoformulation consisting of Streptomycin loaded chitosan-alginate nanoparticles were prepared using ionotropic-pregelation method and optimization was done in terms of polymer concentration, crosslinker concentration and stirring time. The optimal parameters were found to be Chitosan 0.75mg/ml, calcium chloride 1% (w/v) and stirring time 90 min. Polymer (chitosan and sodium-alginate) and cros...
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Rosenkranz, Herbert S. (Columbia University, New York, N.Y.). Macromolecular synthesis and the bactericidal effect of streptomycin. J. Bacteriol. 87:606-603. 1964.-Hydroxylamine, a bacteriostatic agent which inhibits deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis, interferes with the lethal action of streptomycin on growing cells of Escherichia coli. The addition of ...
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rearrangement were elucidated and we assumed that a total synthesis of 1would be a straightforwardmatter. As described below, we were indeed able to accomplish the inaugural total synthesis of phalarine using the rearrangement strategy, although significant obstacles had to be overcome. For a total synthesis of phalarine, it would be best if the rearrangement could be conducted on an advanced-s...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1974
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.27.997